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5.4 Circadian regulation of autonomic nervous system (ANS) activity to attenuating BBB dysfunction of IS Sympathetic and parasympathetic activities exhibit circadian rhythmicity and modulate cerebrovascular function through neurovascular coupling mechanisms (152, 153).Sympathetic activity predominates during the daytime, whereas parasympathetic activity is enhanced at night (154)

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One clinical study from the same year showed a Lactobacillus ferment lysate significantly reduced transepidermal water loss and improved skin hydration