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If you're taking it as part of a multivitamin like Building Blocks, morning with breakfast is the simplest approach

Many people on a B12 shot regimen report a significant decrease in feelings of tiredness or fatigue, making it easier to maintain daily activities and exercise routines

You have any signs of having an allergic reaction, which can possibly lead to anaphylactic shock

Contraindications Vitamin B12 injection is contraindicated in pregnant and lactating women, liver disease, kidney disease, infection, iron deficiency, folic acid deficiency, the patient undergoing treatment that has a direct effect on bone marrow, an allergy to medication, vitamin, preservative or cobalt