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Our study provided evidence that formononetin exerted a significant inhibitory effect on the expression of mTORC1, a negative regulator of ferroptosis ( Furthermore, the persistent activation of the PI3K/Akt/mTORC1 signaling pathway induces resistance to cancer ferroptosis through the upregulation of SREBP1 ( SREBP1, a pivotal transcription factor that regulates the expression of genes involved in lipid homeostasis synthesis ( SCD1 serves as the primary focus of SREBP1, while also functioning as a pivotal enzyme within the MUFA synthesis pathway, thereby governing the modulation of cellular ferroptosis sensitivity ( In summary, as demonstrated in Figure 6, our study provides evidence that formononetin possesses the ability to suppress tumor proliferation both in vitro and in vivo by inducing ferroptosis in breast cancer cells

A thread: Pakistani newspaper Dawn's front pages from 4th december 1971 to 20 December to see how they kept their own people in the dark