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Conditions such as Crohns, coeliac disease or previous gut surgery, and the autoimmune cause behind pernicious anaemia, all affect how well you retain B12

This deficiency may bring down the flow of blood to different parts of the body, including the skin and mucous membranes

Older adults may benefit from getting enough of the vitamin as it appears to play a vital role in maintaining good central vision and protecting against age-related macular degeneration

What we can say with confidence is that the compounds target non-overlapping pathways, show no receptor competition in pharmacological models, and have individual safety profiles that don't predict catastrophic interaction