Thornberry grew up in South Bend, Indiana and did a BSc in Natural Sciences at Muhlenberg College in Allentown, Pennsylvania, She joined Merck Research Laboratories as a biochemist in 1979 and became the director of enzymology in 1990
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In cultured human placental cytotrophoblasts and explants from normotensive and preeclamptic pregnancies, luteolin was identified as a potent inhibitor of sFlt-1 release, reducing secretion by more than 95% compared to vehicle controls ( 4.7 Gynecologic malignancies Gynecologic cancers, including ovarian, cervical, and endometrial cancers, account for around 20% of global female cancer burden ( + /ALDH + stem-like ovarian cancer cells, luteolin decreased sphere formation and downregulated stemness genes (SOX2, OCT4, NANOG)
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