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Instead, its research-relevant effects appear to involve modulation of several signalling pathways most prominently angiogenesis via the VEGF pathway, gastric and gut-lining protective signalling, and to a lesser extent growth factor modulation and nitric oxide system interaction

PEA is an opportunistic molecule that impacts multiple signaling pathways (Bradshaw et al., 2013) Exogenously delivered PEA is hypothesized to affect biosynthetic and metabolic pathways on lipid pathways in part by enhancing the levels of AEA by competing with FAAH the primary enzyme for degrading both NAEs (Rankin and Fowler, 2020)

doi: 10.1016/j.freeradbiomed.2009.07.023 34 SainiRSinghS

A randomized controlled trial involving 264 patients on cancer treatment were assigned into a placebo, while the other group took 50 mg/day of beta-carotene