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Science 292 , 107110 (2001)

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no clear plateau) Zepbound: ~20% to 22.5% (long-term studies) Glycemic Control (T2D): Retatrutide: HbA1c reduction up to ~2.0% (Phase III) Zepbound: Strong, well-established HbA1c reductions (~2.0% to 2.4%) across Phase III trials Durability of Effect: Retatrutide: Sustained weight loss with continued decline over time Zepbound: Durable, but tends to plateau earlier Safety & Tolerability: Retatrutide: Higher rates of GI side effects

The rationale for combining these peptides emerged from observations that they operate through overlapping yet distinct pathways BPC-157 excels at promoting angiogenesis and reducing inflammation, while TB-500 focuses on actin regulation and cellular migration to injury sites