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DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) exhibit differential expression, while ten-eleven translocation methylcytosine dioxygenases (TET1-3) are downregulated in ectopic lesions and eutopic stromal cells, influencing 5-hydroxymethylcytosine levels and epithelial-mesenchymal transition

Some individuals may require weekly injections initially, followed by monthly maintenance injections

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Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States