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According to Bonaca and colleagues, improved blood flow translates to enhanced quality of life, demonstrated by the 2025 results of the STRIDE trial, in which semaglutide significantly increased walking distance and improved function in patients with peripheral arterial disease and type 2 diabetes
An excessive increase in reducing equivalents may modify the redox status of key cysteine residues on proteins, resulting in altered signaling cascades and enzyme functions [21]
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These substances generate oxidative stress, overwhelming the body's antioxidant defenses, including glutathione
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