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Purity is paramount because contaminants or incorrect amino acid sequences can lead to unpredictable off-target effects or a complete lack of efficacy

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Several growth factors have been tested in vitro and most have been shown to successfully decrease cell apoptosis and/or to enhance chondrogenic matrix production, and/or to direct MSC differentiation towards a NP-like phenotype

Doi: Stagni F, Giacomini A, Emili M, Trazzi S, Guidi S, Sassi M, Ciani E, Rimondini R, Bartesaghi R (2016) Short- and Long-Term Effects of Neonatal Pharmacotherapy with Epigallocatechin-3-Gallate on Hippocampal Development in the Ts65Dn Mouse Model of Down Syndrome