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However, while our results corroborate the existence of GLP-1R-associated endosomal signalling, they also suggest that sustained GLP-1R signalling, as indicated by cumulative insulin secretion over pharmacologically relevant timescales, is actually greater with the ligand (exendin-4-C16) with a reduced tendency to recruit mini-G s to Rab5-positive endosomes
It also enhances mitophagy and mitochondrial repair by modulating key autophagy regulators such as PTEN-induced kinase 1 (PINK1) and BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), and activating the Ca 2+ CAMKK2AMPK signaling pathway (30, 31)
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