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Association of neutrophil-lymphocyte ratio with all-cause and cardiovascular mortality in US adults with diabetes and prediabetes: A prospective cohort study

Enhanced colonization of epithelial-adherent pathogens such as AIEC exacerbates mucosal permeability, reshapes microbial community composition, and initiates inflammatory cascades via upregulation of pro-inflammatory genes, ultimately driving intestinal inflammation (81)

This change in structure makes the small intestine inelastic and reduces its motility, making it difficult for stool to pass along the bowels