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Cancer Biol Ther 6:16061613 Conflict of Interest The authors declare that they have no competing interests

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Tirzepatide is a 39-amino-acid synthetic peptide engineered around the native GIP backbone, with selected substitutions that introduce GLP-1 receptor affinity and a C20 fatty di-acid chain at lysine-20 that drives albumin binding and extends the plasma half-life to roughly 120 hours

According to the FDA prescribing information for Zepbound, in the SURMOUNT-1 trial, cholelithiasis was reported in 2.5% of patients receiving tirzepatide compared to 1.0% of patients on placebo