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As it mentioned above, ROS accumulation may cause ER stress ( Selenium is an essential trace element and the function of selenium is mediated in part by its incorporation into slenoproteins, and most of these selenoproteins have antioxidant properties such as glutathione peroxidase (GPX) and selenoprotein P (SEPP1) ( in vivo experiments, the direct regulation of HMSeBA on ER stress signal to porcine intestinal epithelial cells (IPEC-J2) also needs further study

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