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Despite the negative effects of exenatide on bone fracture risk found in the above meta-analysis, a study of 69 metformin-treated subjects with T2D randomized to exenatide twice-daily (n = 36) or insulin glargine once-daily (n = 33) showed that bone mineral density was similar in both groups after the 44-week therapy (between-group difference p = 0.782)
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