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For mouse serum collection, the animals were anaesthetized with isoflurane, and blood was collected via the retro-orbital venous sinus into BD microtainer tubes (BD, 365967)

A systematic review suggested that insufficient cerebral perfusion may be a potential cause of cognitive dysfunction (Wang Y

The failure of these treatments to restore function and slow functional disease progression can be traced to their inability to correct the underlying cause of the dysfunction- diminished synaptic connectivity among neurons in the striatum and neuronal loss in the substantia nigra (SN)

These variants have varied levels of function, ranging from partial to complete loss of function