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In the toes, this can be triggered by various factors ranging from dehydration to nerve issues

There are few other clear human data on serum GPX3 levels in type 1 diabetes, while there are several reports on type 2 diabetes with other comorbidities [21,22,23], including suggestions that the serum/plasma levels are related to oxidative stress and dependent on the extent of disease progression [24]

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In general, the existing drugs have limitations in terms of target specificity, safety, and adherence, and therefore, require further in-depth exploration of precise lipid metabolism interventions (Fig