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Given the stable HRs across the spectrum of frailty, these differences in number needed to treat between frail and non-frail people are primarily driven by the higher number of events among frail patients, which highlights the greater vulnerability of this population. Lower CV risk with SGLT2 inhibitors vs

Crucially, comprehensive drug safety testing in mice indicated no significant adverse effects on myocardial, liver, or renal function markers after 30 days of treatment, suggesting a favorable safety profile [2]

Through increased mitochondrial respiration and oxidative phosphorylation, glucocorticoids directly cause oxidative stress in neurons