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The practical implication is clear: if lowdose metformin begins its work in the brain, future therapies may achieve control with lower exposure or target similar neural circuits more precisely, a direction suggested by the Science Advances research

In diabetes care, they remain part of a structured, guideline-driven approach focused on glycemic control and long-term complication prevention

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Semaglutide activates the GLP-1 pathway, which plays a major role in hunger signals, fullness cues, and insulin release