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B-GOS alone raised blood acetate levels (a short-chain fatty acid), but when it was combined with olanzapine, acetate levels returned to normal, while fat tissue metabolism improved through restored GPR43 receptor expression

Oxidative stress is another of the pathogenic events most frequently linked to obesity, which is primarily triggered by sustained free radical generation as a consequence of mitochondrial electron transport chain overload due to excess calorie intake [43]

ROS can interfere with the functions of macromolecules such as protein oxidation, disintegration of plasma membranes through lipid peroxidation as well as alterations of permeability, integrity and oxidation of RNA and DNA

In ME/CFS and Long COVID, a phenomenon often referred to as the "mitochondrial doom loop" occurs