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These effects are usually temporary and tend to subside as your body adjusts to the medication

16 GLP-1RAs achieve sustained pharmacological effects by resisting degradation by DPP-4 in the body, consequently contributing to hyperglycemia and insulin resistance related to glucose metabolism, 17,18 lipid profile alterations, changes in fat composition, visceral fat accumulation, and obesity related to lipid metabolism, 1921 which constitute the systemic metabolic characteristics of interest in MASLD management

This section is arguably the most practically important part of this entire guide, because GI side effects are the primary reason people discontinue either medication