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Common side effects include nausea, diarrhea, vomiting, constipation, abdominal pain, indigestion and heartburn/acid reflux

Rates of peripheral edema for saxagliptin 2.5 mg and saxagliptin 5 mg versus placebo were 3.6% and 2% versus 3% given as monotherapy, 2.1% and 2.1% versus 2.2% given as add-on therapy to metformin HCl, and 2.4% and 1.2% versus 2.2% given as add-on therapy to glyburide

However, whether a protein of such size could infiltrate the bloodbrain barrier to bind GLP-1R and GIPR in the brain, and whether receptors in the brain are important to the therapeutic effect, still need to be elucidated

The authors concluded that more human trials are needed