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doi: 10.3389/fchem.2025.1536858 Received 29 November 2024 Accepted 27 January 2025 Published 19 March 2025 Volume 13 - 2025 Edited by Federica Aureli, National Institute of Health (ISS), Italy Reviewed by Eric Deconinck, Sciensano (Belgium), Belgium Maria Cristina Gaudiano, National Institute of Health (ISS), Italy Updates Copyright 2025 Blazewicz, Poplawska, Daniszewska, Piorunska and Karynski

Mitochondrial Respiration and Hypoxia Protection The 2003 study by Khvatova, Samartzev, Zagoskin, Prudchenko, and Mikhaleva published in Peptides confirmed that DSIP significantly increased ADP-stimulated mitochondrial respiration in rat brain mitochondria under experimental hypoxia conditions establishing a direct mitochondrial respiratory mechanism for DSIPs stress-protective potency and linking DSIP biology to the emerging field of mitochondria-targeted neuroprotective peptides

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