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Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: a randomized, double-blind, placebo-controlled clinical trial

The nature of the mechanisms underlying these processes is still unknown

Indeed, NRF2 can bind to the promoter regions of pro-inflammatory cytokines (e.g., IL-6 and IL-1), preventing the recruitment of RNA polymerase II and thus inhibiting their gene transcription (Kobayashi et al