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When undertaking significant weight loss with Wegovy, several factors warrant consideration: Caloric restriction may temporarily affect immune cell production and function if nutritional intake is inadequate Rapid metabolic changes during weight loss can be physiologically stressful Improved metabolic health from weight loss may actually enhance immune function over time The NHS offers shingles vaccination (Shingrix) to adults aged 65 years and those in the 70-79 age group as part of a catch-up programme

Although the impact of GLP-1RAs on pancreatic cancer risk remains controversial, emerging evidence suggests that chronic low-grade inflammation and proliferative changes may constitute key pathophysiological mechanisms underlying pancreatic cancer development in patients receiving GLP-1RA therapy [8]

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