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Warmed tissue is more elastic and has better blood flow, allowing the needle to pass through with less resistance and the medication to disperse more evenly

Negative evidence: A study in Indonesian individuals showed that supplementation with glutathione combined with vitamin C, alpha-lipoic acid, and zinc did not significantly lighten skin compared to placebo (Sitohang et al., J Clin Aesthet Dermatol, 2021) [63]