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Therefore, no effect of empagliflozin is anticipated on concomitantly administered drugs that are substrates of the major CYP450 isoforms or UGT1A1, UGT1A3, UGT1A8, UGT1A9, or UGT2B7

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Through the website JASPAR ( we observed that, among the peaks near the TSS in GCLC, a sequence was highly homologous to the NRF2-binding motif (Fig