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Kidney-Affecting Medications: Drugs that can impair kidney function, such as nonsteroidal anti-inflammatory drugs (NSAIDs), angiotensin-converting enzyme (ACE) inhibitors, or certain diuretics, can increase metformin levels and thus the risk of lactic acidosis

Similarly, in the SURMOUNT-1 trial of tirzepatide, lean mass was reduced by 5.67 kg or 10.9% from baseline, with a weight reduction of 22.1 kg or 20.9% (with the highest dose), yielding a fraction of weight lost from lean mass of 25.7% [175]

The teams findings were presented this week at the annual meeting of the American Society for Metabolic and Bariatric Surgery (ASMBS)

There is no published stability data for the two peptides held together in a single solution