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In the pancreas, they enhance glucose-dependent insulin secretion and suppress glucagon release, improving blood sugar control with a low risk of hypoglycemia when used alone (though risk increases when combined with insulin or sulfonylureas)

Clinical Outcomes of Semaglutide in Patients with MASH The phase 3 ESSENCE trial enrolled 800 patients with biopsy-confirmed MASH and fibrosis stage F2F3 and demonstrated that semaglutide 2.4 mg/week produced significant histological and metabolic benefits over 72 weeks

Results Study identification and selection A comprehensive search of ClinicalTrials.gov and relevant databases was conducted to identify studies evaluating tirzepatide and semaglutide

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