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However, since the initial Federal Drug Administration (FDA) approval of IFN-, there has been a trend for breast cancer noted in a study of the British Columbia MS database, evaluating a cohort of 5146 relapsing-onset MS patients and 48,705 person-years of follow-up, that did not reach statistical significance ( Glatiramer Acetate (Copaxone) Glatiramer acetate (GA), was approved in 1996 in the US and in 2001 in Europe for RRMS and became the second non-interferon DMT to be approved for MS