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69 Proteasome activators provide an additional strategy to support ERAD function

Melanotan II, also known as The Barbie Drug,' is an unregulated substance with serious reported side effects that is not safe for consumer use

Moreover, while NfL correlates with disease activity and long-term prognosis, it has not yet been validated as a surrogate endpoint in clinical trials, limiting its utility in regulatory routes

GLP-1R agonists effect(s) on vascular smooth muscle cells are equally important to those on endothelial cells with several favorable responses being reported, including enhanced differentiation, attenuated response to reactive oxygen species, reduced vascular remodeling through improved mitochondrial activity and dynamics, and the prevention of aberrant migration [65]