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Although these findings highlight integrin inhibitors as a viable class of ECM-targeted therapeutics, the majority of candidates remain at the preclinical or early clinical stage, and unresolved issues-including off-target toxicity, uncertainties in dose optimization, and limitations in delivery strategies pose substantial barriers to successful clinical translation (174)

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GLP-1 receptor agonists (semaglutide, liraglutide) are injections that mimic a natural hormone regulating appetite and have demonstrated average weight loss of 815% in clinical trials when combined with lifestyle intervention

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