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However, as GLP-1s expand into broader therapeutic categories, as new molecular analogues and combination regimens enter development pipelines, and as payers and regulators begin demanding evidence beyond empirical efficacy alone, this scientific blind spot is quietly becoming one of the most consequential constraints facing the entire sector

Take home message Mounjaro produces significant weight loss for most people, with typical results of 4% body weight loss in the first month, increasing to 15-20% over 12-18 months

10.1038/nn738 4 ArnettH

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