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IGF-1 LR3 is a recombinant analog of human IGF-1 with an N-terminal extension and an arginine substitution at position 3, which extends its half-life to 2030 hours compared to endogenous IGF-1s half-life of approximately 10 minutes

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In other words, dysregulation of gut microbiota and interaction between some special bacteria, like Bacteroides fragilis and Fusobacterium nucleatum , may cause inflammatory responses, which can lead to cancer development in colorectal epithelial cells in the long term [185]