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J., Stefanski, A., et al

In the trial, dose escalation occurred every 4 weeks from 0.25 mg at baseline to 2.4 mg at the end of the escalation period

Retinoids work by affecting multiple pathways in the skin, not just through speeding skin cell turnover

For example, one study explains that an increase in visceral fat creates a pro-inflammatory environment in the abdomen, which can cause inflammation of the pancreas and potentially result in pancreatitis