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Effective data-driven approaches include: Predictive analytics allow PBMs to intervene before high-cost specialty utilization becomes unmanaged spend Biosimilar opportunity identification requires drug-level data that most PBMs don't surface Claims patterns can reveal clinical gaps, adherence risks and cost optimization opportunities The next wave of specialty cost management will be driven by how well programs use data to act, not just report 2

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Stem Cell Rev Rep 2025;21:182234