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At the end of the 28-day period, study subjects experienced significant weight loss (2.3 kg vs 0.5 kg) compared to saline treated controls in addition to concurrent changes in leptin and adiponectin suggesting reduction in adiposity ( Oxyntomodulin Activates Both GLP-1 and Glucagon Receptors Controlling Energy Balance and Glycaemia Given OXM contains the entire glucagon sequence, it is no surprise that this peptide activates the glucagon receptor ( Glp-1r -/- knock-out mice and not in Gcgr -/- mice, suggesting that the anorectic effects of OXM are mediated through GLP-1R

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