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Notably, while mouse iTregs can be highly suppressive in vivo , human iTregs generated under similar conditions often fail to acquire full regulatory function, highlighting important species-specific differences ( 2.2 The functional antagonism between Th17 cells and Treg cells The functional antagonism between Th17 cells and Treg cells primarily manifests in their reciprocal interactions and regulatory mechanisms within the immune system

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The trial included 60 adult participants (mean age approximately 49) who had clinical follow-up with labs every 2 months for up to 2 years, with some withdrawing early due to spontaneous remission, indication for definitive therapy (e.g., thyroidectomy or radioiodine), or an intolerance to the treatment