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However, in case of the ASCT2, studies showed that cysteine is actually a competitive inhibitor and not a substrate for ASCT2 ( Figure 1 via Multidrug Resistance Protein 1 exporter (MRP1), is cleaved extracellularly by -Glutamyl transferase (GGT) forming -Glutamyl-X substrate and Cysteinyl-Glycine

Combination Approach To treat melasma, you can use a combined approach that includes: Topical treatments like topical glutathiones, azelic acid, niacinamide, vitamin c etc Strict sun protection Oral glutathione supplements paired with Vitamin C and alpha-lipoic acid Results Timeline Glutathione for melasma takes 3-6 months to show visible improvements

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Diabetes (2022) 71(5):103450