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A second mechanism of PKA-independent incretin potentiation of glucose-stimulated insulin secretion (GSIS) involves cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) EPAC2

Existe una advertencia importante en el etiquetado de la FDA : los agonistas GLP-1 y tirzepatida tienen una advertencia de recuadro negro sobre tumores de clulas C tiroideas (carcinoma medular de tiroides) en estudios con roedores

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