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Host interactions have been shown to induce persister formation in numerous pathogens, with the production of reactive oxygen and nitrogen species heavily implicated in the collapse of bacterial metabolic activity and entry into an antibiotic-tolerant state

An earlier controlled study (Coviello 2005) showed that low-dose HCG maintained intratesticular testosterone in a dose-dependent way when the body's own gonadotropins were suppressed the mechanistic basis for using it during testosterone therapy