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Once their buffering capacity is exceeded, sustained elevation of subplasmalemmal Ca 2+ favors prolonged SOCE activation and a self-reinforcing injury loop ( 2+ clearance reinforce one another

Lowers a signaling protein (TGF-1) and reduces cell stress (measured by an antioxidant enzyme called SOD), both of which contribute to hair follicles shrinking due to the hormone DHT

doi:10.1016/j.cell.2007.07.035

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