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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]

285 When UA levels are increased, RAGE signaling becomes activated, that ultimately lead to endothelial dysfunction, is a key feature of various cardiovascular diseases

Stem cells, germline cells, and certain immune cells retain meaningful telomerase activity, which is one reason these cell populations maintain their regenerative capacity over a lifetime

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