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Neuroinflammation and oxidative reaction are among the pivotal factors for neurodegenerative conditions, contributing to the progression of NDs, such as Parkinsons disease (PD), Alzheimers disease (AD), multiple sclerosis (MS) and Huntingtons disease (HD)

The studies opened new insights, not least the equal importance of IGF-I and IGF-II in fetal growth, reducing birth weight by about 60% in both Igf1 knock-out ( Igf1 ko) and Igf2 ko animals and demonstrating that the previous perceived concept that there was a fetal (IGF-II) and a postnatal (IGF-I) form of IGF was incorrect

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Individuals with significant renal impairment or a history of oxalate nephropathy (kidney stones) should strictly avoid high-dose IV vitamin C as well