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A recent study from our research group might give some hints about the underlying pathogenesis [2]

Dual knockdown of SPHKAP and VAPB in INS-1 832/3 cells led to widespread changes in PKA phosphorylation of several MICOS complex components downstream of GLP-1R activation, suggesting that ERMCS-localised GLP-1R signalling modulates the activity of the MICOS complex (Supplementary Fig

Fonseca VA, Alvarado-Ruiz R, Raccah D, et al