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Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

More importantly, oxidant enzymes including mitochondrial electron transport chain complex I, complex II, complex III, as well as SODs, xanthine oxidase (XO), NO synthases (NOS), cytochrome p 450 enzymes (CYP), NADPH oxidases (NOX) and lipoxygenase (LOX), generate O 2 radicals which are quickly converted into H 2 O 2 , OH and other radicals [26]

doi: 10.3389/fonc.2023.1085581 106 LeeJRohJ-L

For IBD specifically, this combination addresses both the structural mucosal deficit and the immune dysregulation that prevents natural repair