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When a treatment proves this effective for both type 2 diabetes and weight management, it becomes a blockbuster

With regard to catalytic mechanism, all the seleno-GPxs share the common pathway which starts with the binding of hydroperoxides and GSH at the catalytic and thiol binding motifs, respectively [8, 11,12,13,14,15,16,17,18]

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At tissue level, RAS (renin-angiotensin system) can be upregulated with non-hemodynamic effects ( Several studies reported that inappropriate ANGII/AT1R activation occurs because of different mechanisms, particularly in patients with T2DM