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10.1016/j.lfs.2019.116786 49 MikamiM.KitaharaM.KitanoM.ArikiY.MimakiY.SashidaY.et al (1999)

What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology

While our findings regarding serum HDL-c levels contradicted those of Wang et al .[62], who reported no statistical significance, although its essential to note that their focus was primarily on breast cancer, which differs from our studys scope [62].Moreover, our study did not find statistical significance in cholesterol and triglyceride levels, aligning with findings from other studies suggesting that these parameters may not be directly associated with disease initiation or progression from radiation exposure [63, 64, 65]

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