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Not dosing every 7 days prevents you from hitting steady state and creates an environment of erratic side effects (both positive and negative), in addition to increasing the likelihood of negative side effects (think: nausea, GI issues, etc) as the medication works its way into and out of your system

Since even low doses of biotin can interfere with thyroid test results, the ATA recommends that patients stop taking biotin for at least two days before regular thyroid blood testing

The effects of high-dose esomeprazole on gastric and oesophageal acid exposure and molecular markers in Barretts oesophagus