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After SCI, astrocytes surrounding the lesion center undergo a specific reactive transformation termed astrogliosis which is typically characterized by cellular hypertrophy, proliferation, and process extension as well as a myriad of gene expression changes linked to both reparative and degenerative processes [7,8]

Transfersomal nanovesicles for nose-to-brain delivery of ofloxacin for better management of bacterial meningitis: formulation, optimization by box-behnken design, characterization and in vivo pharmacokinetic study

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The mechanism works regardless of starting body fat level, though individuals with BMIs above 40 may benefit from the full 12mg dose more than those in the 30-35 BMI range